GPR55: signaling pathways and functions
نویسندگان
چکیده
Background We have recently shown that the G protein-coupled receptor 55 (GPR55) mediates intracellular effects of cannabinoids and other, non-cannabinoid ligands in addition to the classical cannabinoid 1 (CB1) and 2 (CB2) receptors. Here we show different signaling pathways triggered by GPR55 in response to a panel of its agonists. In addition the cytoskeleton rearrangement mediated by GPR55 is investigated.
منابع مشابه
Functional characterization of the novel cannabinoid receptor GPR55 and its modulation by CB1 and CB2 receptors
We have recently shown that the G protein-coupled receptor 55 (GPR55) mediates intracellular effects of cannabinoids and other, non-cannabionid, ligands in addition to the classical cannabinoid 1 (CB1R) and 2 (CB2R) receptors. Here we show that the presence of either CB1R or CB2R alters the signaling pathways of GPR55. HEK-293 cells stably expressing either the GPR55 receptor alone or in combin...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2009